Take 310 N to 75 and then take 75 N to Atlanta ( it take about 5 hours). Once you get on 310 make sure you stick to the business route though because it take forever if you go through all the little towns. Mapquest has the directions.
If you connect to 75 though I-10 you go about an hour and half out of way because you go further east than you need to.
I drove this route regularly from Tally town to SC when I was a student at FSU